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Histomorphologic and ultrastructural recovery of myopathy in rats treated with low-level laser therapy.
Servetto, Natalia; Cremonezzi, David; Simes, Juan Carlos; Di Pietro, Antonio; Campana, Vilma R.
  • Servetto N; Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, 5000, Córdoba, Argentina.
  • Cremonezzi D; Cátedra de Patología, Carrera de Medicina, Universidad Nacional de La Rioja, De la Fuente S/N, 5300, La Rioja, Argentina.
  • Simes JC; I Cátedra de Patología, Hospital Nacional de Clínicas, Universidad Nacional de Córdoba, Santa Rosa 1564, 5000, Córdoba, Argentina.
  • Di Pietro A; Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, 5000, Córdoba, Argentina.
  • Campana VR; Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, 5000, Córdoba, Argentina.
Lasers Med Sci ; 32(4): 841-849, 2017 May.
Article en En | MEDLINE | ID: mdl-28280999
ABSTRACT
The purpose of the present work was to study the effect of low-level laser therapy (LLLT) helium-neon (He-Ne) and gallium arsenide (Ga-As) laser on the histomorphology of muscle and mitochondria in experimental myopathy in rats. Thirty Suquía strain female rats were distributed in groups (A) control (intact), (B) injured, (C) injured and treated with He-Ne laser, (D) injured and treated with Ga-As laser, (E) irradiated with He-Ne laser on the non-injured muscle, and (F) irradiated with Ga-As laser on the non-injured muscle. Myopathy was induced by injecting 0.05 mg/rat/day of adrenaline in the left gastrocnemius muscle at the same point on five consecutive days, in groups B, C, and D. LLLT was applied with 9.5 J cm-2 daily for seven consecutive days in groups C, D, E, and F. The muscles were examined with optic and electronic microscopy. The inflammation was classified as absent, mild, and intense and the degree of mitochondrial alteration was graded I, II, III, and IV. Categorical data were statistically analyzed by Chi-square and the Fisher-Irwin Bilateral test, setting significant difference at p < 0.05. The damage found in muscle and mitochondria histomorphology in animals with induced myopathy (B) was intense or severe inflammation with grade III or IV of mitochondrial alteration. They underwent significant regression (p < 0.001) compared with the groups treated with He-Ne (C) and Ga-As (D) laser, in which mild or moderate inflammation was seen and mitochondrial alteration grades I and II, recovering normal myofibrillar architecture. No differences were found between the effects caused by the two lasers, or between groups A, E, and F. Group A was found to be different from B, C, and D (p < 0.001). LLLT in experimental myopathy caused significant muscular and mitochondrial morphologic recovery.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Terapia por Luz de Baja Intensidad / Enfermedades Musculares Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Terapia por Luz de Baja Intensidad / Enfermedades Musculares Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article