Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart.

Rawal, Shruti; Munasinghe, Pujika Emani; Nagesh, Prashanth Thevkar; Lew, Jason Kar Sheng; Jones, Gregory T; Williams, Michael J A; Davis, Philip; Bunton, Dick; Galvin, Ivor F; Manning, Patrick; Lamberts, Regis R; Katare, Rajesh

Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart.

Rawal, Shruti; Munasinghe, Pujika Emani; Nagesh, Prashanth Thevkar; Lew, Jason Kar Sheng; Jones, Gregory T; Williams, Michael J A; Davis, Philip; Bunton, Dick; Galvin, Ivor F; Manning, Patrick; Lamberts, Regis R; Katare, Rajesh.

Rawal S; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand.
Munasinghe PE; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand.
Nagesh PT; Department of Microbiology and Immunology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Lew JKS; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand.
Jones GT; Department of Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Williams MJA; Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Davis P; Department of Cardiothoracic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Bunton D; Department of Cardiothoracic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Galvin IF; Department of Cardiothoracic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Manning P; Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Lamberts RR; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand.
Katare R; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand rajesh.katare@otago.ac.nz.

Clin Sci (Lond) ; 131(9): 847-863, 2017 May 01.

Article en En | MEDLINE | ID: mdl-28289072

Asunto(s)

Diabetes Mellitus Tipo 2/genética; Regulación hacia Abajo; MicroARNs/genética; Miocardio/metabolismo; Animales; Western Blotting; Diferenciación Celular/genética; Línea Celular; Células Cultivadas; Factor de Crecimiento del Tejido Conjuntivo/genética; Factor de Crecimiento del Tejido Conjuntivo/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/patología; Fibrosis/genética; Fibrosis/metabolismo; Glucosa/farmacología; Humanos; Ratones; Miocardio/patología; Miocitos Cardíacos/citología; Miocitos Cardíacos/efectos de los fármacos; Miocitos Cardíacos/metabolismo; Miofibroblastos/citología; Miofibroblastos/metabolismo; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; Receptor Tipo I de Factor de Crecimiento Transformador beta; Receptores de Factores de Crecimiento Transformadores beta/genética; Receptores de Factores de Crecimiento Transformadores beta/metabolismo; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Transducción de Señal/efectos de los fármacos; Transducción de Señal/genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación hacia Abajo / MicroARNs / Diabetes Mellitus Tipo 2 / Miocardio Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article

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