MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.

Zhang, Zi-Wei; Guo, Rui-Wei; Lv, Jin-Lin; Wang, Xian-Mei; Ye, Jin-Shan; Lu, Ni-Hong; Liang, Xing; Yang, Li-Xia

Zhang, Zi-Wei; Guo, Rui-Wei; Lv, Jin-Lin; Wang, Xian-Mei; Ye, Jin-Shan; Lu, Ni-Hong; Liang, Xing; Yang, Li-Xia.

Zhang ZW; Department of Postgraduate, Kunming Medical University, Yunnan, 650500, China; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Guo RW; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Lv JL; Department of Postgraduate, Kunming Medical University, Yunnan, 650500, China; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Wang XM; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Ye JS; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Lu NH; Department of Postgraduate, Kunming Medical University, Yunnan, 650500, China; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Liang X; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China.
Yang LX; Department of Cardiology, Kunming General Hospital of Chengdu Military Area, China. Electronic address: doctorlxyang@126.com.

Biochem Biophys Res Commun ; 486(2): 414-422, 2017 04 29.

Article en En | MEDLINE | ID: mdl-28315335

Asunto(s)

Células Endoteliales/efectos de los fármacos; Insulina/farmacología; MicroARNs/genética; Receptor IGF Tipo 1/genética; Serina-Treonina Quinasas TOR/genética; Animales; Desdiferenciación Celular/efectos de los fármacos; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Células Endoteliales/citología; Células Endoteliales/metabolismo; Regulación de la Expresión Génica; Insulina/metabolismo; Ratones; Ratones Endogámicos C57BL; MicroARNs/metabolismo; Imitación Molecular; Músculo Liso Vascular/citología; Músculo Liso Vascular/efectos de los fármacos; Músculo Liso Vascular/metabolismo; Oligorribonucleótidos/genética; Oligorribonucleótidos/metabolismo; Cultivo Primario de Células; Receptor IGF Tipo 1/metabolismo; Transducción de Señal; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

Differentiation; Insulin; Proliferation; Rapamycin resistance; Vascular smooth muscle cells; miR-99a

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor IGF Tipo 1 / MicroARNs / Células Endoteliales / Serina-Treonina Quinasas TOR / Insulina Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article

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