Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.

Zhang, Long; Li, Liang; Gao, Ganglong; Wei, Gaigai; Zheng, Yansen; Wang, Chunmei; Gao, Na; Zhao, Yongliang; Deng, Jiong; Chen, Huaqing; Sun, Jialiang; Li, Dali; Zhang, Xueli; Liu, Mingyao

Zhang, Long; Li, Liang; Gao, Ganglong; Wei, Gaigai; Zheng, Yansen; Wang, Chunmei; Gao, Na; Zhao, Yongliang; Deng, Jiong; Chen, Huaqing; Sun, Jialiang; Li, Dali; Zhang, Xueli; Liu, Mingyao.

Zhang L; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Li L; Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Gao G; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Wei G; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zheng Y; Southern Medical University, Fengxian Hospital, Shanghai, 201499, China.
Wang C; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Gao N; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zhao Y; Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Deng J; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Chen H; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Sun J; Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai, 200025, China.
Li D; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zhang X; Southern Medical University, Fengxian Hospital, Shanghai, 201499, China.
Liu M; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.

Int J Cancer ; 140(12): 2734-2747, 2017 06 15.

Article en En | MEDLINE | ID: mdl-28316092

Asunto(s)

Amidohidrolasas/genética; Neoplasias Colorrectales/genética; Regulación Neoplásica de la Expresión Génica; Estrés Oxidativo; Receptores Acoplados a Proteínas G/genética; Animales; Apoptosis/genética; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Western Blotting; Línea Celular Tumoral; Proliferación Celular/genética; Colitis/complicaciones; Neoplasias Colorrectales/complicaciones; Neoplasias Colorrectales/metabolismo; Progresión de la Enfermedad; Proteínas Ligadas a GPI/genética; Perfilación de la Expresión Génica/métodos; Glutatión/metabolismo; Células HEK293; Células HT29; Humanos; Ratones Endogámicos C57BL; Ratones Noqueados; Receptores Acoplados a Proteínas G/metabolismo; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Regulación hacia Arriba

Palabras clave

GPRC5A; NF-κB; VNN1; colorectal cancer; oxidative stress

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Regulación Neoplásica de la Expresión Génica / Estrés Oxidativo / Receptores Acoplados a Proteínas G / Amidohidrolasas Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article

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