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A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.
Wang, Xu; Cao, Wei; Zhang, Jianjun; Yan, Ming; Xu, Qin; Wu, Xiangbing; Wan, Lixin; Zhang, Zhiyuan; Zhang, Chenping; Qin, Xing; Xiao, Meng; Ye, Dongxia; Liu, Yuyang; Han, Zeguang; Wang, Shaomeng; Mao, Li; Wei, Wenyi; Chen, Wantao.
  • Wang X; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Cao W; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Zhang J; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yan M; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Xu Q; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wu X; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Wan L; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zhang Z; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Zhang C; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Qin X; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Xiao M; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Ye D; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Liu Y; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Han Z; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang S; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Mao L; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wei W; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
  • Chen W; Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
EMBO J ; 36(9): 1243-1260, 2017 05 02.
Article en En | MEDLINE | ID: mdl-28320739
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Xantenos / Ubiquitina-Proteína Ligasas / Inhibidores Enzimáticos / Ubiquitinación / Proteína Potenciadora del Homólogo Zeste 2 / Antineoplásicos Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Xantenos / Ubiquitina-Proteína Ligasas / Inhibidores Enzimáticos / Ubiquitinación / Proteína Potenciadora del Homólogo Zeste 2 / Antineoplásicos Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article