Role of single disulfide linkages in the folding and activity of scyllatoxin-based BH3 domain mimetics.

Arachchige, Danushka; Margaret Harris, M; Coon, Zachary; Carlsen, Jacob; Holub, Justin M

Arachchige, Danushka; Margaret Harris, M; Coon, Zachary; Carlsen, Jacob; Holub, Justin M.

Arachchige D; Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA.
Margaret Harris M; Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA.
Coon Z; Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA.
Carlsen J; Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA.
Holub JM; Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA.

J Pept Sci ; 23(5): 367-373, 2017 May.

Article en En | MEDLINE | ID: mdl-28326661

Asunto(s)

Materiales Biomiméticos/síntesis química; Materiales Biomiméticos/farmacología; Disulfuros/química; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Materiales Biomiméticos/química; Diseño de Fármacos; Humanos; Modelos Moleculares; Unión Proteica; Pliegue de Proteína; Estructura Secundaria de Proteína; Proteínas Proto-Oncogénicas c-bcl-2/química; Venenos de Escorpión/química; Venenos de Escorpión/metabolismo; Proteína X Asociada a bcl-2/química

Palabras clave

BH3 domain mimetic; anti-apoptotic Bcl-2 proteins; apoptosis; disulfide linkage; ligand binding; scyllatoxin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-bcl-2 / Materiales Biomiméticos / Disulfuros Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article

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