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Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.
Rodriguez-Broadbent, Henry; Law, Philip J; Sud, Amit; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hänninen, Ulrika A; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Ripatti, Samuli; Eriksson, Johan G; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Palotie, Aarno; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Mecklin, Jukka-Pekka; Al-Tassan, Nada A; Palles, Claire; Martin, Lynn; Barclay, Ella; Farrington, Susan M; Timofeeva, Maria N; Meyer, Brian F; Wakil, Salma M; Campbell, Harry; Smith, Christopher G; Idziaszczyk, Shelley; Maughan, Timothy S; Kaplan, Richard; Kerr, Rachel; Kerr, David; Passarelli, Michael N; Figueiredo, Jane C; Buchanan, Daniel D; Win, Aung K; Hopper, John L; Jenkins, Mark A; Lindor, Noralane M; Newcomb, Polly A; Gallinger, Steven; Conti, David; Schumacher, Fred.
  • Rodriguez-Broadbent H; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
  • Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
  • Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
  • Palin K; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Tuupanen S; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Gylfe A; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Hänninen UA; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Cajuso T; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Tanskanen T; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Kondelin J; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Kaasinen E; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Sarin AP; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Ripatti S; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Eriksson JG; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Rissanen H; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Knekt P; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Pukkala E; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Jousilahti P; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.
  • Salomaa V; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
  • Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Renkonen-Sinisalo L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Lepistö A; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Böhm J; Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Mecklin JP; National Institute for Health and Welfare, Helsinki, Finland.
  • Al-Tassan NA; Folkhälsan Research Centre, Helsinki, Finland.
  • Palles C; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Martin L; National Institute for Health and Welfare, Helsinki, Finland.
  • Barclay E; National Institute for Health and Welfare, Helsinki, Finland.
  • Farrington SM; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
  • Timofeeva MN; Faculty of Social Sciences, University of Tampere, Tampere, Finland.
  • Meyer BF; National Institute for Health and Welfare, Helsinki, Finland.
  • Wakil SM; National Institute for Health and Welfare, Helsinki, Finland.
  • Campbell H; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Smith CG; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
  • Idziaszczyk S; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA.
  • Maughan TS; Department of Neurology, Massachusetts General Hospital, Boston, MA.
  • Kaplan R; Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
  • Kerr R; Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
  • Kerr D; Department of Pathology, Central Finland Central Hospital, Jyväskylä, Finland.
  • Passarelli MN; Department of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä, Finland.
  • Figueiredo JC; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Buchanan DD; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, United Kingdom.
  • Win AK; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, United Kingdom.
  • Hopper JL; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, United Kingdom.
  • Jenkins MA; Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
  • Lindor NM; Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
  • Newcomb PA; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Gallinger S; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Conti D; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Schumacher F; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Int J Cancer ; 140(12): 2701-2708, 2017 06 15.
Article en En | MEDLINE | ID: mdl-28340513
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Análisis de la Aleatorización Mendeliana / Hiperlipidemias Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Análisis de la Aleatorización Mendeliana / Hiperlipidemias Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article