Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease.

Nielsen, Rune B; Egefjord, Lærke; Angleys, Hugo; Mouridsen, Kim; Gejl, Michael; Møller, Arne; Brock, Birgitte; Brændgaard, Hans; Gottrup, Hanne; Rungby, Jørgen; Eskildsen, Simon F; Østergaard, Leif

Nielsen, Rune B; Egefjord, Lærke; Angleys, Hugo; Mouridsen, Kim; Gejl, Michael; Møller, Arne; Brock, Birgitte; Brændgaard, Hans; Gottrup, Hanne; Rungby, Jørgen; Eskildsen, Simon F; Østergaard, Leif.

Nielsen RB; Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark. Electronic address: rbaeksager@cfin.au.dk.
Egefjord L; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Angleys H; Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark.
Mouridsen K; Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark.
Gejl M; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Møller A; PET-Center, Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark.
Brock B; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Brændgaard H; Dementia Clinic, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Gottrup H; Dementia Clinic, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Rungby J; Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.
Eskildsen SF; Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark.
Østergaard L; Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark; Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark.

Alzheimers Dement ; 13(10): 1143-1153, 2017 Oct.

Article en En | MEDLINE | ID: mdl-28343848

Asunto(s)

Enfermedad de Alzheimer/complicaciones; Circulación Cerebrovascular/fisiología; Disfunción Cognitiva/etiología; Hemodinámica/fisiología; Enfermedades Neurodegenerativas/etiología; Anciano; Anciano de 80 o más Años; Enfermedad de Alzheimer/diagnóstico por imagen; Corteza Cerebral/diagnóstico por imagen; Corteza Cerebral/patología; Disfunción Cognitiva/diagnóstico por imagen; Femenino; Humanos; Procesamiento de Imagen Asistido por Computador; Imagen por Resonancia Magnética; Masculino; Microvasos/patología; Microvasos/fisiopatología; Persona de Mediana Edad; Enfermedades Neurodegenerativas/diagnóstico; Pruebas Neuropsicológicas; Perfusión

Palabras clave

Alzheimer's disease; Capillary dysfunction; Capillary transit time heterogeneity (CTH); Cerebral blood flow (CBF); Cerebral blood volume (CBV); Cortical thinning; Hypoxia; Magnetic resonance imaging (MRI); Microvascular dysfunction; Neurodegeneration; Neurovascular dysfunction; Perfusion imaging; Relative transit time heterogeneity (RTH); Tissue oxygen tension (P(t)O(2))

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Circulación Cerebrovascular / Enfermedades Neurodegenerativas / Enfermedad de Alzheimer / Disfunción Cognitiva / Hemodinámica Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2017 Tipo del documento: Article

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