Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting.

Velazquez, Victoria M; Meadows, Aaron S; Pineda, Ricardo J; Camboni, Marybeth; McCarty, Douglas M; Fu, Haiyan.

Velazquez VM; Center for Vaccine and Immunology, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Meadows AS; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Pineda RJ; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Camboni M; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
McCarty DM; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; Department of Pediatrics, School of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Fu H; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

Mol Ther Methods Clin Dev ; 4: 159-168, 2017 Mar 17.

Article en En | MEDLINE | ID: mdl-28345001