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Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles.
Kim, Jin; Yang, Kisuk; Lee, Jong Seung; Hwang, Yong Hwa; Park, Hyun-Ji; Park, Kook In; Lee, Dong Yun; Cho, Seung-Woo.
  • Kim J; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Yang K; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Lee JS; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Hwang YH; Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science and Technology (INST), Hanyang University, Seoul, 04763, Republic of Korea.
  • Park HJ; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Park KI; Severance Children's Hospital, Department of Pediatrics and BK21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Lee DY; Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science and Technology (INST), Hanyang University, Seoul, 04763, Republic of Korea.
  • Cho SW; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Macromol Biosci ; 17(8)2017 08.
Article en En | MEDLINE | ID: mdl-28394476
Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esferoides Celulares / Nanopartículas / Neurogénesis / Células-Madre Neurales / Feto / Grafito Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esferoides Celulares / Nanopartículas / Neurogénesis / Células-Madre Neurales / Feto / Grafito Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article