Human endogenous retroviruses and multiple sclerosis: Causation, association, or after-effect?
Mult Scler
; 23(8): 1050-1055, 2017 Jul.
Article
en En
| MEDLINE
| ID: mdl-28406354
ABSTRACT
From the early days of MS discovery, infections have been proposed as a possible cause of the disease. In the last three decades, an association between human endogenous retrovirus expression and MS has been further investigated and confirmed. Nevertheless, the role of such retroviruses in the disease needs clarification. In this review, we introduce MSRV/HERV-W and describe its association with MS. We then summarize the evidence for the involvement of MSRV/HERV-W in the aetiology and progression of MS and its possible role as biomarker and drug target. Biological mechanisms for HERV effects in MS may involve the activation of innate immune pathways by the envelope protein of MSRV (MSRVEnv). In addition to in vitro and experimental studies, further insight on how HERVs may influence immune-mediated pathology in MS may also come from the use of antiretroviral treatments in patients.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Productos del Gen env
/
Retrovirus Endógenos
/
Antirretrovirales
/
Esclerosis Múltiple
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article