Nitric oxide signaling during meiotic cell cycle regulation in mammalian oocytes.
Front Biosci (Schol Ed)
; 9(3): 307-318, 2017 06 01.
Article
en En
| MEDLINE
| ID: mdl-28410121
ABSTRACT
Nitric oxide (NO) acts as a major signal molecules and modulate physiology of mammalian oocytes. Ovarian follicles generate large amount of NO through nitric oxide synthase (NOS) pathway to maintain diplotene arrest in preovulatory oocytes. Removal of oocytes from follicular microenvironment or follicular rupture during ovulation disrupt the flow of NO from granulosa cells to the oocyte that results a transient decrease of oocyte cytoplasmic NO level. Decreased NO level reduces cyclic nucleotides level by inactivating guanylyl cyclases directly or indirectly. The reduced cyclic nucleotides level modulate specific phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation. These changes result in maturation promoting factor (MPF) destabilization that finally triggers meiotic resumption from diplotene as well as metaphase-II (M-II) arrest in most of the mammalian species.
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Banco de datos:
MEDLINE
Asunto principal:
Oocitos
/
Meiosis
/
Óxido Nítrico
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article