Expression and modulation of a retrovirus-associated antigen by murine melanoma cells.
Cancer Res
; 48(17): 4954-8, 1988 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-2842042
ABSTRACT
The antigen recognized by the monoclonal antibody MM2-9B6 is specific for melanomas originating in C57BL/6 mice. It is expressed by three melanomas of independent origin and not by normal or fetal tissues, by a wide variety of other nonmelanoma tumors in C57BL/6 mice, or even by melanomas syngeneic to other strains of mice. We have demonstrated that the expression of the relevant antigen is dependent on the replication and budding of a B-tropic ecotropic murine retrovirus. The relationship between the expression of this virus and carcinogenic progression may yield important insights into the cascade of events leading to neoplastic transformation.
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Banco de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Melanoma Experimental
/
Antígenos de Neoplasias
/
Antígenos Virales
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
1988
Tipo del documento:
Article