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The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.
Yao, Lihang; Ramirez, Andres D; Roecker, Anthony J; Fox, Steven V; Uslaner, Jason M; Smith, Sean M; Hodgson, Robert; Coleman, Paul J; Renger, John J; Winrow, Christopher J; Gotter, Anthony L.
  • Yao L; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Ramirez AD; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Roecker AJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Fox SV; Department of In Vivo Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Uslaner JM; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Smith SM; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Hodgson R; Department of In Vivo Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Coleman PJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Renger JJ; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Winrow CJ; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
  • Gotter AL; Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania, USA.
J Neurochem ; 142(2): 204-214, 2017 07.
Article en En | MEDLINE | ID: mdl-28444767
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Triazoles / Acetilcolina / Histamina / Corteza Prefrontal / Antagonistas de los Receptores de Orexina / Hipocampo / Área Hipotalámica Lateral Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Triazoles / Acetilcolina / Histamina / Corteza Prefrontal / Antagonistas de los Receptores de Orexina / Hipocampo / Área Hipotalámica Lateral Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article