Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination.
Prenat Diagn
; 37(7): 666-672, 2017 Jul.
Article
en En
| MEDLINE
| ID: mdl-28453880
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the accuracy of fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient (ADC) determination to predict postnatal renal function (nadir creatinine at 1 year and eGFR) of men with posterior urethral valves (PUV).METHODS:
Between 2003 and 2014, 11 MRI were performed on fetuses (between 28 and 32 weeks) in whom second trimester sonography suggested severe bilateral urinary tract anomalies, suspected of PUV.RESULTS:
The ADC of the 11 fetuses ranged from 1.3 to 2.86 mm2 s-1 (median = 1.79 mm2 s-1 , normal range for fetal kidney 1.1-1.8). Two pregnancies with ADC > 2.6 mm2 s-1 were interrupted; the autopsy confirmed PUV and Potter syndrome. For the remaining nine babies, the follow-up was 5.4 years (0.8-10). Four children with abnormal ADC (1.8-2.3) had chronic kidney disease. The remaining five cases with normal nadir creatinine and eGFR had normal ADC. One case with unilateral elevated ADC had a poor ipsilateral renal function on dimercaptosuccinic acid scan.CONCLUSION:
Here, it seems that diffusion-weighted magnetic resonance imaging with ADC determination could be useful in accurately evaluating fetal kidneys in PUV and predicting renal function. It may be an additional, non-invasive method when biologic and sonographic findings are inconclusive, especially in the case of oligohydramnios. Further studies are needed to confirm our data. © 2017 John Wiley & Sons, Ltd.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Uretra
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Anomalías Urogenitales
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Imagen de Difusión por Resonancia Magnética
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Año:
2017
Tipo del documento:
Article