The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.

Kitajima, S; Yoshida, A; Kohno, S; Li, F; Suzuki, S; Nagatani, N; Nishimoto, Y; Sasaki, N; Muranaka, H; Wan, Y; Thai, T C; Okahashi, N; Matsuda, F; Shimizu, H; Nishiuchi, T; Suzuki, Y; Tominaga, K; Gotoh, N; Suzuki, M; Ewen, M E; Barbie, D A; Hirose, O; Tanaka, T; Takahashi, C

Kitajima, S; Yoshida, A; Kohno, S; Li, F; Suzuki, S; Nagatani, N; Nishimoto, Y; Sasaki, N; Muranaka, H; Wan, Y; Thai, T C; Okahashi, N; Matsuda, F; Shimizu, H; Nishiuchi, T; Suzuki, Y; Tominaga, K; Gotoh, N; Suzuki, M; Ewen, M E; Barbie, D A; Hirose, O; Tanaka, T; Takahashi, C.

Kitajima S; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yoshida A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Kohno S; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Li F; Department of Cellular Transplantation Biology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
Suzuki S; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Nagatani N; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Nishimoto Y; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sasaki N; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Muranaka H; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Wan Y; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Thai TC; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Okahashi N; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Matsuda F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Shimizu H; Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan.
Nishiuchi T; Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan.
Suzuki Y; Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan.
Tominaga K; Division of Functional Genomics, Advanced Science Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan.
Gotoh N; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Chiba, Japan.
Suzuki M; Division of Molecular Therapy, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
Ewen ME; Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Barbie DA; Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Hirose O; Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA.
Tanaka T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Takahashi C; Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Oncogene ; 36(36): 5145-5157, 2017 09 07.

Article en En | MEDLINE | ID: mdl-28481867

Asunto(s)

Neoplasias de la Mama/patología; Autorrenovación de las Células/efectos de los fármacos; Resistencia a Antineoplásicos; Interleucina-6/metabolismo; Mitocondrias/patología; Proteína de Retinoblastoma/metabolismo; Tamoxifeno/farmacología; Animales; Antineoplásicos Hormonales/farmacología; Apoptosis/efectos de los fármacos; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/metabolismo; Diferenciación Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Ácidos Grasos/química; Ácidos Grasos/metabolismo; Femenino; Humanos; Interleucina-6/genética; Metaboloma; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Proteína de Retinoblastoma/genética; Factor de Transcripción STAT3/genética; Factor de Transcripción STAT3/metabolismo; Células Tumorales Cultivadas; Proteína p53 Supresora de Tumor/fisiología; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tamoxifeno / Neoplasias de la Mama / Proteína de Retinoblastoma / Interleucina-6 / Resistencia a Antineoplásicos / Autorrenovación de las Células / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2017 Tipo del documento: Article

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