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Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
Steinman, Jonathan B; Santarossa, Cristina C; Miller, Rand M; Yu, Lola S; Serpinskaya, Anna S; Furukawa, Hideki; Morimoto, Sachie; Tanaka, Yuta; Nishitani, Mitsuyoshi; Asano, Moriteru; Zalyte, Ruta; Ondrus, Alison E; Johnson, Alex G; Ye, Fan; Nachury, Maxence V; Fukase, Yoshiyuki; Aso, Kazuyoshi; Foley, Michael A; Gelfand, Vladimir I; Chen, James K; Carter, Andrew P; Kapoor, Tarun M.
  • Steinman JB; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States.
  • Santarossa CC; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States.
  • Miller RM; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States.
  • Yu LS; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States.
  • Serpinskaya AS; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
  • Furukawa H; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Morimoto S; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Tanaka Y; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Nishitani M; Pharmaceutical Research Division, Takeda Pharmaceuticals Ltd, Kanagawa, Japan.
  • Asano M; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Zalyte R; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
  • Ondrus AE; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, United States.
  • Johnson AG; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, United States.
  • Ye F; Department of Molecular and Cellular Physiology, Stanford University, Stanford, United States.
  • Nachury MV; Department of Molecular and Cellular Physiology, Stanford University, Stanford, United States.
  • Fukase Y; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Aso K; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Foley MA; Tri-Institutitional Therapeutics Discovery Institute, New York, United States.
  • Gelfand VI; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
  • Chen JK; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, United States.
  • Carter AP; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
  • Kapoor TM; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States.
Elife ; 62017 05 19.
Article en En | MEDLINE | ID: mdl-28524820
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Dineínas / Inhibidores Enzimáticos Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Dineínas / Inhibidores Enzimáticos Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article