Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates.
Antiviral Res
; 144: 44-47, 2017 08.
Article
en En
| MEDLINE
| ID: mdl-28529000
ABSTRACT
Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-peak viremia in NHPs neutralized infectious DENV although RNAemia remained detectable post-treatment; differential interaction of human IgGs with macaque Fc-gamma receptors may delay clearance of neutralized DENV. Our findings suggest useful antiviral utility of VIS513 and highlight an important consideration when evaluating virological endpoints of trials for anti-DENV biologics.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
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Dengue
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Virus del Dengue
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Factores Inmunológicos
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Inmunoterapia
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Anticuerpos Antivirales
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article