[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.
Theranostics
; 7(6): 1422-1436, 2017.
Article
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| MEDLINE
| ID: mdl-28529627
ABSTRACT
Microglial activation is a key pathological feature of Alzheimer's disease (AD). PET imaging of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo. Here we assessed flutriciclamide ([18F]GE-180), a new second-generation TSPO-PET radiotracer, for its ability to monitor response to LM11A-31, a novel AD therapeutic in clinical trials. AD mice displaying pathology were treated orally with LM11A-31 for 3 months. Subsequent [18F]GE-180-PET imaging revealed significantly lower signal in cortex and hippocampus of LM11A-31-treated AD mice compared to those treated with vehicle, corresponding with decreased levels of TSPO immunostaining and microglial Iba1 immunostaining. In addition to detecting decreased microglial activation following LM11A-31 treatment, [18F]GE-180 identified activated microglia in AD mice with greater sensitivity than another second-generation TSPO radiotracer, [18F]PBR06. Together, these data demonstrate the promise of [18F]GE-180 as a potentially sensitive tool for tracking neuroinflammation in AD mice and for monitoring therapeutic modulation of microglial activation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carbazoles
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Morfolinas
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Receptores de GABA
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Microglía
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Radiofármacos
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Enfermedad de Alzheimer
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Isoleucina
Tipo de estudio:
Diagnostic_studies
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Evaluation_studies
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article