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Comparison of Autologous and Unrelated Transplants for Cytogenetically Normal Acute Myelogenous Leukemia.
Mizutani, Motonori; Takami, Akiyoshi; Hara, Masahiko; Mizuno, Shohei; Yanada, Masamitsu; Chou, Takaaki; Uchiyama, Hitoji; Ohashi, Kazuteru; Miyamoto, Toshihiro; Ozawa, Yukiyasu; Imataki, Osamu; Kobayashi, Naoki; Uchida, Naoyuki; Kanamori, Heiwa; Kamimura, Tomohiko; Eto, Tetsuya; Onizuka, Makoto; Tanaka, Junji; Atsuta, Yoshiko; Yano, Shingo.
  • Mizutani M; Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan.
  • Takami A; Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan. Electronic address: takami-knz@umin.ac.jp.
  • Hara M; Department of Medical Innovation, Osaka University Hospital, Suita, Japan.
  • Mizuno S; Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan.
  • Yanada M; Department of Hematology, School of Medicine, Fujita Health University, Toyoake, Japan.
  • Chou T; Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan.
  • Uchiyama H; Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
  • Ohashi K; Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
  • Miyamoto T; Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka, Japan.
  • Ozawa Y; Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
  • Imataki O; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University Hospital, Kagawa, Japan.
  • Kobayashi N; Department of Hematology, Sapporo Hokuyu Hospital, Hokkaido, Japan.
  • Uchida N; Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan.
  • Kanamori H; Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
  • Kamimura T; Department of Hematology, Harasanshin Hospital, Fukuoka, Japan.
  • Eto T; Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
  • Onizuka M; Department of Hematology and Oncology, Tokai University School of Medicine, Kanagawa, Japan.
  • Tanaka J; Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan.
  • Atsuta Y; Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yano S; Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Biol Blood Marrow Transplant ; 23(9): 1447-1454, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28533061
ABSTRACT
Allogeneic stem cell transplantation (SCT) from an HLA-matched sibling donor (MSD) is a postremission treatment that offers a potential cure for adults with cytogenetically normal (CN) acute myelogenous leukemia (AML) in first complete remission (CR1). The best alternative in the absence of an MSD remains unclear, however. The aim of this study was to retrospectively compare the outcomes of autologous peripheral blood stem cell transplantation (auto-PBSCT; n = 177) and allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor (MUD; n = 173) in adult patients with CN-AML/CR1. Both the multivariate analysis (hazard ratio [HR], 1.18; 95% confidence interval [CI], 0.71 to 1.97; P = .53) and propensity score models (HR, 1.40; 95% CI, 0.80 to 2.43; P = .24) indicated that the leukemia-free survival (LFS) rate of auto-PBSCT was not significantly different from that of MUD-BMT. These results suggest that in the absence of an available MSD, auto-PBSCT remains a viable alternative as postremission therapy in patients with CN-AML/CR1.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Médula Ósea / Trasplante de Células Madre de Sangre Periférica / Donante no Emparentado / Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Médula Ósea / Trasplante de Células Madre de Sangre Periférica / Donante no Emparentado / Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2017 Tipo del documento: Article