Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20).

Wong, Kit Man; Horton, Kathryn J; Coveler, Andrew L; Hingorani, Sunil R; Harris, William P

Wong, Kit Man; Horton, Kathryn J; Coveler, Andrew L; Hingorani, Sunil R; Harris, William P.

Wong KM; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Horton KJ; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Coveler AL; Department of Medicine, University of Washington Medical Center, 1959 NE Pacific Street, Box 354760, Seattle, WA, USA.
Hingorani SR; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Harris WP; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Curr Oncol Rep ; 19(7): 47, 2017 Jul.

Article en En | MEDLINE | ID: mdl-28589527

Asunto(s)

Adenocarcinoma/tratamiento farmacológico; Carcinoma Ductal Pancreático/tratamiento farmacológico; Ácido Hialurónico/genética; Hialuronoglucosaminidasa/uso terapéutico; Proteínas Recombinantes/uso terapéutico; Adenocarcinoma/genética; Adenocarcinoma/patología; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/aislamiento & purificación; Carcinogénesis/efectos de los fármacos; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/patología; Sistemas de Liberación de Medicamentos; Matriz Extracelular/genética; Matriz Extracelular/metabolismo; Humanos; Ácido Hialurónico/aislamiento & purificación; Hialuronoglucosaminidasa/genética; Metástasis de la Neoplasia; Proteínas Recombinantes/genética; Células del Estroma/efectos de los fármacos

Palabras clave

CD44; Convection; Diffusion; Extracellular matrix; Gemcitabine; Glycosaminoglycan; Hyaluronan; Hyaluronic acid; Immunotherapy; Interstitial fluid pressure; KPC mice; Nab-paclitaxel; PEGPH20; Pancreatic ductal adenocarcinoma; Pegylated recombinant human hyaluronidase; RHAMM; Stromal resistance; Thromboembolic events; Tumor microenvironment; Tumor perfusion; Tumor stroma

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Recombinantes / Adenocarcinoma / Carcinoma Ductal Pancreático / Ácido Hialurónico / Hialuronoglucosaminidasa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article

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