Measurement of propericiazine in plasma by capillary gas chromatography and selected ion monitoring detection.
Biomed Mass Spectrom
; 12(1): 25-9, 1985 Jan.
Article
en En
| MEDLINE
| ID: mdl-2859055
ABSTRACT
A new method, based upon a selective extraction and gas chromatographic/mass spectrometric analysis, was developed to monitor the effect of combined haemoperfusion-haemodialysis treatment in a case of propericiazine poisoning. The method relies on the selected ion monitoring of the acetate derivatives of propericiazine and its internal standard fluphenazine, after their extraction from 1 ml of alkalinized plasma with n-hexaneisopropanol (82, v/v), back-extraction into an acidified water phase, realkalinization and extraction with n-hexane isopropanol, derivatization with acetic anhydride and gas chromatography on a short (12 m) OV-101 fused silica capillary column. The described procedure is specific and provides between-assay variability of 4.8% CV at 5 micrograms 1(-1) plasma concentration. The method enables quantification down to 1 microgram 1(-1) and hence demonstrates sufficient sensitivity to permit pharmacokinetic or drug monitoring studies.
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Banco de datos:
MEDLINE
Asunto principal:
Fenotiazinas
/
Cromatografía de Gases y Espectrometría de Masas
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
1985
Tipo del documento:
Article