Safety and acceptability of transcranial direct current stimulation for the acute treatment of major depressive episodes: Analysis of individual patient data.
J Affect Disord
; 221: 1-5, 2017 10 15.
Article
en En
| MEDLINE
| ID: mdl-28623732
ABSTRACT
BACKGROUND:
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that has been increasingly used for major depressive disorder (MDD) treatment. Although studies in healthy volunteers showed that the technique is well-tolerated, tDCS safety and acceptability have not been sufficiently explored in patients with MDD.METHODS:
We collected individual patient data from 6 randomized clinical trials that had been previously identified in a systematic review and meta-analysis. Primary outcomes were safety (rate of adverse events) and acceptability (rate of dropouts). Secondary outcomes were clinical, demographic and treatment predictors of the primary outcomes.RESULTS:
Dropout rates between active (8.8%) and sham (12%) groups were not significantly different (OR= 0.7, p=0.38). Adverse event rates between active (73.5%) and sham (68.3%) groups were not significantly different (OR= 1.4, p= 0.23). Higher current densities were associated with lower adverse event rates.LIMITATIONS:
Dropout reasons were not systematically reported and adverse events were not collected using questionnaires standardized across studies.CONCLUSIONS:
Active tDCS is as acceptable and safe as sham tDCS, as found in randomized clinical trials of MDD.Palabras clave
Texto completo:
1
Ejes tematicos:
Pesquisa_clinica
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Depresivo Mayor
/
Estimulación Transcraneal de Corriente Directa
Tipo de estudio:
Clinical_trials
/
Evaluation_studies
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Prognostic_studies
/
Systematic_reviews
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2017
Tipo del documento:
Article