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Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina, Marija; Hong, Liu; Horrocks, Mathew H; Ludtmann, Marthe H; Choi, Minee L; Hughes, Craig D; Ruggeri, Francesco S; Guilliams, Tim; Buell, Alexander K; Lee, Ji-Eun; Gandhi, Sonia; Lee, Steven F; Bryant, Clare E; Vendruscolo, Michele; Knowles, Tuomas P J; Dobson, Christopher M; De Genst, Erwin; Klenerman, David.
  • Iljina M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Hong L; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Horrocks MH; Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing, 100084, China.
  • Ludtmann MH; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Choi ML; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QR, UK.
  • Hughes CD; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Ruggeri FS; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Guilliams T; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
  • Buell AK; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Lee JE; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Gandhi S; Present address: Healx Ltd., St John's Innovation Centre, Cowley Road, Cambridge, CB4 0WS, UK.
  • Lee SF; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Bryant CE; Present address: Institute of Physical Biology, University of Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Vendruscolo M; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • Knowles TPJ; Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Dobson CM; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  • De Genst E; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
  • Klenerman D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
BMC Biol ; 15(1): 57, 2017 07 03.
Article en En | MEDLINE | ID: mdl-28673288
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alfa-Sinucleína / Anticuerpos de Dominio Único Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alfa-Sinucleína / Anticuerpos de Dominio Único Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article