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Myristoylation: An Important Protein Modification in the Immune Response.
Udenwobele, Daniel Ikenna; Su, Ruey-Chyi; Good, Sara V; Ball, Terry Blake; Varma Shrivastav, Shailly; Shrivastav, Anuraag.
  • Udenwobele DI; Department of Biology, University of Winnipeg, Winnipeg, MB, Canada.
  • Su RC; Department of Biochemistry, University of Nigeria, Nsukka, Enugu, Nigeria.
  • Good SV; JC Wilt Infectious Diseases Research Institute, National HIV and Retrovirology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
  • Ball TB; Department of Biology, University of Winnipeg, Winnipeg, MB, Canada.
  • Varma Shrivastav S; JC Wilt Infectious Diseases Research Institute, National HIV and Retrovirology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
  • Shrivastav A; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Front Immunol ; 8: 751, 2017.
Article en En | MEDLINE | ID: mdl-28713376
ABSTRACT
Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino group of an N-terminal glycine residue of many eukaryotic and viral proteins. The ubiquitous eukaryotic enzyme, N-myristoyltransferase, catalyzes the myristoylation process. Precisely, attachment of a myristoyl group increases specific protein-protein interactions leading to subcellular localization of myristoylated proteins with its signaling partners. The birth of the field of myristoylation, a little over three decades ago, has led to the understanding of the significance of protein myristoylation in regulating cellular signaling pathways in several biological processes especially in carcinogenesis and more recently immune function. This review discusses myristoylation as a prerequisite step in initiating many immune cell signaling cascades. In particular, we discuss the hitherto unappreciated implication of myristoylation during myelopoiesis, innate immune response, lymphopoiesis for T cells, and the formation of the immunological synapse. Furthermore, we discuss the role of myristoylation in inducing the virological synapse during human immunodeficiency virus infection as well as its clinical implication. This review aims to summarize existing knowledge in the field and to highlight gaps in our understanding of the role of myristoylation in immune function so as to further investigate into the dynamics of myristoylation-dependent immune regulation.
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