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Regenerative Potential of Spermatogonial Stem Cells, Endothelial Progenitor Cells, and Epithelial Progenitor Cells of C57Bl/6 Male Mice with Metabolic Disorders.
Skurikhin, E G; Pakhomova, A V; Pershina, O V; Ermolaeva, L A; Krupin, V A; Ermakova, N N; Pan, E S; Kudryashova, A I; Rybalkina, O Yu; Pavlovskaya, T B; Litvyakov, N V; Goldberg, V E; Dygai, A M.
  • Skurikhin EG; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Pakhomova AV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. angelinapakhomova2011@gmail.com.
  • Pershina OV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Ermolaeva LA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Krupin VA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Ermakova NN; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Pan ES; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Kudryashova AI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Rybalkina OY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Pavlovskaya TB; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Litvyakov NV; Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Goldberg VE; Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Dygai AM; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
Bull Exp Biol Med ; 163(2): 239-244, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28726193
The properties of spermatogonial stem cells, endothelial progenitor cells, and the epithelial progenitors of C57Bl/6 mice under conditions of metabolic disorders were studied using the model of busulfan-induced suppression of spermatogenesis and in vitro culture technique. Spermatogonial stem cells CD117-CD90+ and epithelial progenitors CD45-CD31-Sca-1+CD49f+ derived from the testes of mice with metabolic disturbances demonstrated 17- and 28-fold increase in the respective cell mass and generated cell colonies in vitro. In contrast, spermatogonial stem cells with immune phenotype CD51-CD24+CD52+ had reduced selfrenewal capacity. Spermatogonial stem cells CD117-CD90+ and CD117+CD90+ as well as endothelial progenitors CD45-CD31+ derived from the testes of donor mice with metabolic disorders demonstrated high transplantation capacity in C57Bl/6 mouse testes damaged by cytostatic busulfan.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre / Células Progenitoras Endoteliales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre / Células Progenitoras Endoteliales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article