Genomic characterization of Zika virus isolated from Indonesia.
Virology
; 510: 248-251, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28755588
ABSTRACT
Zika virus (ZIKV) JMB-185 strain was isolated from a febrile patient in Jambi, Indonesia in 2014. To understand its genetic characteristics, we performed whole genome sequencing using the Ion Torrent PGM platform on the supernatant of the first passage. The phylogenetic analysis showed that the isolate was not closely related to the Brazilian ZIKV associated with microcephaly or isolates from the recent Singapore Zika outbreak. Molecular evolution analysis indicated that JMB-185 strain may have been circulating in the Southeast Asia region, including Indonesia since 2000. We observed high nucleotide sequence identity between Indonesia, Thailand, Singapore, and American strains although unique amino acid substitutions were also observed. This report provides information on the genomic characteristics of Indonesian ZIKV which may be used for further studies.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Genoma Viral
/
Análisis de Secuencia de ADN
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Virus Zika
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Infección por el Virus Zika
País como asunto:
Asia
Idioma:
En
Año:
2017
Tipo del documento:
Article