Deaminative Strategy for the Visible-Light-Mediated Generation of Alkyl Radicals.
Angew Chem Int Ed Engl
; 56(40): 12336-12339, 2017 09 25.
Article
en En
| MEDLINE
| ID: mdl-28762257
ABSTRACT
A deaminative strategy for the visible-light-mediated generation of alkyl radicals from redox-activated primary amine precursors is described. Abundant and inexpensive primary amine feedstocks, including amino acids, were converted in a single step into redox-active pyridinium salts and subsequently into alkyl radicals by reaction with an excited-state photocatalyst. The broad synthetic potential of this protocol was demonstrated by the alkylation of a number of heteroarenes under mild conditions.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Año:
2017
Tipo del documento:
Article