Prognostic Factors in Syphilitic Uveitis.
Ophthalmology
; 124(12): 1808-1816, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-28779905
ABSTRACT
PURPOSE:
To identify predictors of treatment success in syphilitic uveitis (SU).DESIGN:
Retrospective multicentric analysis of patients treated for SU.PARTICIPANTS:
A total of 95 eyes (66 patients, mean [standard deviation] aged 49 [12.5] years, 31 [47%] of whom were human immunodeficiency virus [HIV]+) were analyzed.METHODS:
Activity of SU was assessed at 1 week and 1 month after treatment onset, and at last follow-up. Improvement was defined by a ≥2-step decrease of both anterior chamber and vitreous haze inflammation levels, and by the size reduction in chorioretinal lesions. MAIN OUTCOMEMEASURES:
Recovery was defined as the resolution of inflammation in all anatomic structures at 1 month.RESULTS:
Panuveitis and posterior uveitis were the most frequent findings. Inflammatory parameters were higher in HIV+ patients. Recovery was reported in 65% and 85% of eyes at 1 month and at last follow-up, respectively. In multivariate analysis, after adjusting for initial best-corrected visual acuity and the antimicrobial treatment regimen, clinical improvement at 1 week (corrected risk ratios [cRR], 3.5 [2.3-3.8]; P = 0.001) was predictive of recovery at 1 month, whereas the use of periocular dexamethasone injections (cRR, 0.05 [0.02-0.6]; P = 0.01) and methylprednisolone pulses negatively affected the outcomes of eyes.CONCLUSIONS:
Early improvement is the strongest predictor of ophthalmological recovery in SU.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Uveítis
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Sífilis
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Infecciones Bacterianas del Ojo
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Antibacterianos
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2017
Tipo del documento:
Article