Effects of calcitonin on orthodontic tooth movement and associated root resorption in rats.
Acta Odontol Scand
; 75(8): 595-602, 2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-28814141
ABSTRACT
OBJECTIVES:
Our main aim was to evaluate the effects of calcitonin (CT) on orthodontic tooth movement (OTM) and orthodontic root resorption in a rat model. MATERIAL ANDMETHODS:
Eighty male Wistar rats were randomly divided into five groups. Rats in the negative control group were not given any appliances or injections. All the remaining rats were used to establish a model of OTM. The positive control group were then injected with normal saline, while rats in the three experimental groups were injected with 0.2 IU, 1 IU or 5 IU/kg/day CT. Nickel-titanium closed-coil springs were used to deliver an initial 50 g mesial force to the left maxillary first molar for 14 days in rats in the positive control group and the experimental groups. Each group was randomly subdivided into two groups, one for analysis of tooth movement, tissue changes and tartrate-resistant acid phosphatase (TRAP)-positive cells in alveolar bone, the other to examine root resorption by scanning electron microscopy.RESULTS:
The OTM distance, the number of force-induced osteoclasts and root resorption areas were significantly decreased in CT-injected rats in a dose-dependent manner.CONCLUSIONS:
Administration of CT reduces the root resorption area and may therefore be effective as a novel adjunctive orthodontic approach to diminish undesired tooth movement via enhancing anchorage or preventing relapse after OTM.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteoclastos
/
Resorción Radicular
/
Raíz del Diente
/
Calcitonina
/
Fosfatasa Ácida Tartratorresistente
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article