Identifying cisplatin-induced kidney damage in paediatric oncology patients.
Pediatr Nephrol
; 33(9): 1467-1474, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-28821959
ABSTRACT
Cisplatin is one chemotherapeutic agent used to treat childhood cancer in numerous treatment protocols, including as a single agent. It is likely to remain in clinical use over the long term. However, cisplatin-related toxicities, including neurotoxicity and nephrotoxicity, are common, affecting treatment, day-to-day life and survival of such children. With one in 700 young adults having survived childhood cancer, patients who have completed chemotherapy that includes cisplatin can experience long-term morbidity due to treatment-related adverse reactions. A better understanding of these toxicities is essential to facilitate prevention, surveillance and management. This review article discusses the effect of cisplatin-induced nephrotoxicity (Cis-N) in children and considers the underlying mechanisms. We focus on clinical features and identification of Cis-N (e.g. investigations and biomarkers) and the importance of magnesium homeostasis and supplementation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cisplatino
/
Lesión Renal Aguda
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Riñón
/
Magnesio
/
Antineoplásicos
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Child
/
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article