Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.
ACS Med Chem Lett
; 8(8): 802-807, 2017 Aug 10.
Article
en En
| MEDLINE
| ID: mdl-28835792
ABSTRACT
From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Año:
2017
Tipo del documento:
Article