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Nanoparticle-encapsulated emodin decreases diabetic neuropathic pain probably via a mechanism involving P2X3 receptor in the dorsal root ganglia.
Li, Lin; Sheng, Xuan; Zhao, Shanhong; Zou, Lifang; Han, Xinyao; Gong, Yingxin; Yuan, Huilong; Shi, Liran; Guo, Lili; Jia, Tianyu; Liu, Shuangmei; Wu, Bing; Yi, Zhihua; Liu, Hui; Gao, Yun; Li, Guilin; Li, Guodong; Zhang, Chunping; Xu, Hong; Liang, Shangdong.
  • Li L; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Sheng X; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Zhao S; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Zou L; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Han X; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Gong Y; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Yuan H; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Shi L; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Guo L; First Clinical Department, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Jia T; First Clinical Department, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Liu S; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Wu B; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Yi Z; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Liu H; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Gao Y; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Li G; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Li G; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Zhang C; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Xu H; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Liang S; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, Jiangxi, People's Republic of China.
Purinergic Signal ; 13(4): 559-568, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28840511
ABSTRACT
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). More than 90% of all cases of DM belong to type 2 diabetes mellitus (T2DM). Emodin is the main active component of Radix et rhizoma rhei and has anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. Nanoparticle encapsulation of drugs is beneficial for drug targeting and bioavailability as well as for lowering drug toxicity side effects. The aim of this study was to investigate the effects of nanoparticle-encapsulated emodin (nano emodin) on diabetic neuropathic pain (DNP) mediated by the Purin 2X3 (P2X3) receptor in the dorsal root ganglia (DRG). Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) values in T2DM rats were lower than those of control rats. MWT and TWL in T2DM rats treated with nano emodin were higher compared with those in T2DM rats. Expression levels of P2X3 protein and messenger RNA (mRNA) in the DRG of T2DM rats were higher than those of controls, while levels in T2DM rats treated with nano emodin were significantly lower than those of the T2DM rats. Phosphorylation and activation of ERK1/2 in the T2DM DRG were decreased by nano emodin treatment. Nano emodin significantly inhibited currents activated by the P2X3 agonist α,ß-meATP in HEK293 cells transfected with the P2X3 receptor. Therefore, nano emodin treatment may relieve DNP by decreasing excitatory transmission mediated by the DRG P2X3 receptor in T2DM rats.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Emodina / Neuropatías Diabéticas / Receptores Purinérgicos P2X3 / Nanoconjugados / Ganglios Espinales Tipo de estudio: Clinical_trials Límite: Animals / Humans / Male Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Emodina / Neuropatías Diabéticas / Receptores Purinérgicos P2X3 / Nanoconjugados / Ganglios Espinales Tipo de estudio: Clinical_trials Límite: Animals / Humans / Male Idioma: En Año: 2017 Tipo del documento: Article