Isocoumarin derivatives from the endophytic fungus, Pestalotiopsis sp.
Fitoterapia
; 122: 115-118, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28842359
ABSTRACT
Five new isocoumarin derivatives, pestalactone A-C (1-3) and pestapyrone D-E (4-5), together with two known compounds (6-7) were isolated from the solid cultures of the endophytic fungus Pestalotiopsis sp. obtained from Photinia frasery. Their structures were mainly determined by extensive spectroscopic analysis, Mo2(OCOCH3)4-induced electronic circular dichroism (ECD), and ECD calculation. Compounds 1 and 2 were rare isocoumarin derivatives and derived from distinctive polyketide pathways. Compound 3 exhibited potent antifungal activity against Candida glabrata (ATCC 90030) with an MIC50 value of 3.49±0.21µg/mL.
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Banco de datos:
MEDLINE
Asunto principal:
Xylariales
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Antifúngicos
Idioma:
En
Año:
2017
Tipo del documento:
Article