NLRP3 and Potassium Efflux Drive Rapid IL-1ß Release from Primary Human Monocytes during <i>Toxoplasma gondii</i> Infection.

Gov, Lanny; Schneider, Christine A; Lima, Tatiane S; Pandori, William; Lodoen, Melissa B

NLRP3 and Potassium Efflux Drive Rapid IL-1ß Release from Primary Human Monocytes during Toxoplasma gondii Infection.

Gov, Lanny; Schneider, Christine A; Lima, Tatiane S; Pandori, William; Lodoen, Melissa B.

Gov L; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697; and Institute for Immunology, University of California, Irvine, Irvine, CA 92697.
Schneider CA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697; and Institute for Immunology, University of California, Irvine, Irvine, CA 92697.
Lima TS; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697; and Institute for Immunology, University of California, Irvine, Irvine, CA 92697.
Pandori W; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697; and Institute for Immunology, University of California, Irvine, Irvine, CA 92697.
Lodoen MB; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697; and Institute for Immunology, University of California, Irvine, Irvine, CA 92697 mlodoen@uci.edu.

J Immunol ; 199(8): 2855-2864, 2017 10 15.

Article en En | MEDLINE | ID: mdl-28904126

Asunto(s)

Inflamasomas/metabolismo; Interleucina-1beta/metabolismo; Monocitos/inmunología; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Potasio/metabolismo; Toxoplasma/inmunología; Toxoplasmosis/inmunología; Diferenciación Celular; Células Cultivadas; Furanos; Compuestos Heterocíclicos de 4 o más Anillos/farmacología; Humanos; Indenos; Macrófagos/inmunología; Monocitos/parasitología; Proteína con Dominio Pirina 3 de la Familia NLR/antagonistas & inhibidores; Cultivo Primario de Células; Proteolisis/efectos de los fármacos; Sulfonamidas; Sulfonas/farmacología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Potasio / Toxoplasma / Monocitos / Toxoplasmosis / Interleucina-1beta / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article

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