Tumor-suppressive miR-145 co-repressed by TCF4-ß-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer.

Wang, Wei; Xiao, Xin; Chen, Xu; Huo, Yi; Xi, Wen-Jin; Lin, Zhi-Feng; Zhang, Dan; Li, Yu-Fang; Yang, Fan; Wen, Wei-Hong; Yang, An-Gang; Wang, Tao

Wang, Wei; Xiao, Xin; Chen, Xu; Huo, Yi; Xi, Wen-Jin; Lin, Zhi-Feng; Zhang, Dan; Li, Yu-Fang; Yang, Fan; Wen, Wei-Hong; Yang, An-Gang; Wang, Tao.

Wang W; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Xiao X; Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Chen X; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Huo Y; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Xi WJ; Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Lin ZF; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Zhang D; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Li YF; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Yang F; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Wen WH; Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Yang AG; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Wang T; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.

Int J Cancer ; 142(2): 308-321, 2018 01 15.

Article en En | MEDLINE | ID: mdl-28921929

Asunto(s)

Neoplasias Colorrectales/patología; Regulación Neoplásica de la Expresión Génica; Neoplasias Hepáticas/secundario; MicroARNs/genética; Complejo Represivo Polycomb 2/metabolismo; Factor de Transcripción 4/metabolismo; beta Catenina/metabolismo; Animales; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Metástasis Linfática; Masculino; Ratones; Ratones Desnudos; Estadificación de Neoplasias; Complejo Represivo Polycomb 2/genética; Factor de Transcripción 4/genética; Ensayos Antitumor por Modelo de Xenoinjerto; beta Catenina/genética

Palabras clave

Wnt signaling; colorectal cancer; histone trimethylation; tumor-suppressive miRNA

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Regulación Neoplásica de la Expresión Génica / MicroARNs / Beta Catenina / Complejo Represivo Polycomb 2 / Factor de Transcripción 4 / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article

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