Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice.
Pharm Biol
; 55(1): 2123-2128, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28938867
ABSTRACT
CONTEXT Tea (Camellia sinensis (L.) Kuntze [Theaceae]) is used to induce urination and inducing nervous excitation. Green and black teas have multifarious physiological functions. The different effects of green and black tea aqueous extracts (GTEs and BTEs) on hyperuricemia are not definitely reported. OBJECTIVE:
The different effects of GTEs and BTEs on lowering serum uric acid (UA) in hyperuricemic mice were determined. MATERIALS ANDMETHODS:
Kunming mice were divided into nine groups (n = 6/each group). GTEs and BTEs at the doses of 0.5, 1 and 2 g/kg were orally administrated to mice for seven days, respectively. Hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) activities as mechanisms of actions were assessed.RESULTS:
Research indicated that the LD50 of tea extract is greater than 2 g/kg in mice. UA levels were suppressed significantly with dose-dependent treatment of 0.5, 1 and 2 g/kg BTEs (up to 25.5%, 28.7% and 29.8%, respectively); the serum UA levels were decreased by GTEs but not significant. The activities of XOD and ADA in high dose (2 g/kg) groups of both GTEs and BTEs were notably lower than those of the model group. DISCUSSION ANDCONCLUSIONS:
The results suggested that both GTEs and BTEs have hypouricaemic and renal protective effects on hyperuricemic mice and the latter one was better. Our study sheds light on the research and development of anti-hyperuricemic functional foods and drugs from tea.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Té
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Ácido Úrico
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Extractos Vegetales
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Hiperuricemia
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article