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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Lasko, Loren M; Jakob, Clarissa G; Edalji, Rohinton P; Qiu, Wei; Montgomery, Debra; Digiammarino, Enrico L; Hansen, T Matt; Risi, Roberto M; Frey, Robin; Manaves, Vlasios; Shaw, Bailin; Algire, Mikkel; Hessler, Paul; Lam, Lloyd T; Uziel, Tamar; Faivre, Emily; Ferguson, Debra; Buchanan, Fritz G; Martin, Ruth L; Torrent, Maricel; Chiang, Gary G; Karukurichi, Kannan; Langston, J William; Weinert, Brian T; Choudhary, Chunaram; de Vries, Peter; Van Drie, John H; McElligott, David; Kesicki, Ed; Marmorstein, Ronen; Sun, Chaohong; Cole, Philip A; Rosenberg, Saul H; Michaelides, Michael R; Lai, Albert; Bromberg, Kenneth D.
  • Lasko LM; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Jakob CG; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Edalji RP; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Qiu W; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Montgomery D; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Digiammarino EL; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Hansen TM; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Risi RM; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Frey R; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Manaves V; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Shaw B; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Algire M; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Hessler P; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Lam LT; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Uziel T; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Faivre E; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Ferguson D; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Buchanan FG; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Martin RL; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Torrent M; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Chiang GG; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Karukurichi K; eFFECTOR Therapeutics, 11180 Roselle St, Suite A, San Diego, California 92121, USA.
  • Langston JW; Petra Pharma Corporation, 430 E. 29th St, Suite 435, New York, New York 10016, USA.
  • Weinert BT; Faraday Pharmaceuticals, 1616 Eastlake Ave E., Suite 560, Seattle, Washington 98102, USA.
  • Choudhary C; Department of Proteomics, the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
  • de Vries P; Department of Proteomics, the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
  • Van Drie JH; Cascadian Therapeutics, Inc., 2601 Fourth Avenue, Suite 500, Seattle, Washington 98121, USA.
  • McElligott D; Van Drie Research, 109 Millpond, Andover, Massachusetts 01845, USA.
  • Kesicki E; Accelerator Corporation, 430 East 29th St, New York, New York 10106, USA.
  • Marmorstein R; Petra Pharma Corporation, 430 E. 29th St, Suite 435, New York, New York 10016, USA.
  • Sun C; Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Cole PA; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Rosenberg SH; Johns Hopkins University, 725 N. Wolfe St, Baltimore, Maryland 21205, USA.
  • Michaelides MR; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Lai A; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
  • Bromberg KD; Discovery, Global Pharmaceutical Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.
Nature ; 550(7674): 128-132, 2017 10 05.
Article en En | MEDLINE | ID: mdl-28953875
Asunto(s)
Linaje de la Célula; Compuestos Heterocíclicos de 4 o más Anillos/farmacología; Compuestos Heterocíclicos de 4 o más Anillos/uso terapéutico; Histona Acetiltransferasas/antagonistas & inhibidores; Neoplasias/tratamiento farmacológico; Neoplasias/patología; Factores de Transcripción p300-CBP/antagonistas & inhibidores; Acetilcoenzima A/metabolismo; Animales; Antineoplásicos/química; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Unión Competitiva; Biocatálisis/efectos de los fármacos; Dominio Catalítico/efectos de los fármacos; Línea Celular Tumoral; Linaje de la Célula/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Cristalografía por Rayos X; Inhibidores Enzimáticos/farmacología; Inhibidores Enzimáticos/uso terapéutico; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Neoplasias Hematológicas/tratamiento farmacológico; Neoplasias Hematológicas/enzimología; Neoplasias Hematológicas/patología; Compuestos Heterocíclicos de 4 o más Anillos/química; Histona Acetiltransferasas/química; Histona Acetiltransferasas/metabolismo; Humanos; Masculino; Ratones; Ratones SCID; Modelos Moleculares; Neoplasias/enzimología; Neoplasias de la Próstata Resistentes a la Castración/tratamiento farmacológico; Neoplasias de la Próstata Resistentes a la Castración/enzimología; Neoplasias de la Próstata Resistentes a la Castración/patología; Conformación Proteica; Receptores Androgénicos/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto; Factores de Transcripción p300-CBP/química; Factores de Transcripción p300-CBP/metabolismo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linaje de la Célula / Histona Acetiltransferasas / Factores de Transcripción p300-CBP / Compuestos Heterocíclicos de 4 o más Anillos / Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linaje de la Célula / Histona Acetiltransferasas / Factores de Transcripción p300-CBP / Compuestos Heterocíclicos de 4 o más Anillos / Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Año: 2017 Tipo del documento: Article