KV channel trafficking and control of vascular tone.
Microcirculation
; 25(1)2018 01.
Article
en En
| MEDLINE
| ID: mdl-28963858
ABSTRACT
Membrane potential is a principal regulator of arterial contractility. Arterial smooth muscle cells express several different types of ion channel that control membrane potential, including KV channels. KV channel activation leads to membrane hyperpolarization, resulting in inhibition of voltage-dependent Ca2+ channels, a reduction in [Ca2+ ]i , and vasodilation. In contrast, KV channel inhibition leads to membrane depolarization and vasoconstriction. The ability of KV channels to regulate arterial contractility is dependent upon the number of plasma membrane-resident channels and their open probability. Here, we will discuss mechanisms that alter the surface abundance of KV channel proteins in arterial smooth muscle cells and the functional consequences of such regulation. Cellular processes that will be described include those that modulate KV channel transcription, retrograde and anterograde trafficking, and protein degradation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Canales de Potasio con Entrada de Voltaje
/
Hemodinámica
Límite:
Animals
/
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article