Estimating HPV DNA Deposition Between Sexual Partners Using HPV Concordance, Y Chromosome DNA Detection, and Self-reported Sexual Behaviors.
J Infect Dis
; 216(10): 1210-1218, 2017 12 05.
Article
en En
| MEDLINE
| ID: mdl-28968731
ABSTRACT
Background:
Detection of human papillomavirus (HPV) DNA in genital samples may not always represent true infections but may be depositions from infected sexual partners. We examined whether sexual risk factors and a biomarker (Y chromosome DNA) were associated with genital HPV partner concordance and estimated the fraction of HPV detections potentially attributable to partner deposition.Methods:
The HITCH study enrolled young women attending a university or college in Montréal, Canada, and their male partners, from 2005 to 2010. We tested baseline genital samples for Y chromosome DNA and HPV DNA using polymerase chain reaction.Results:
Type-specific HPV concordance was 42.4% in partnerships where at least one partner was HPV DNA positive. Y chromosome DNA predicted type-specific HPV concordance in univariate analyses, but in multivariable models the independent predictors of concordance were days since last vaginal sex (26.5% higher concordance 0-1 vs 8-14 days after last vaginal sex) and condom use (22.6% higher concordance in never vs always users). We estimated that 14.1% (95% confidence interval [CI], 6.3-21.9%) of HPV DNA detections in genital samples were attributable to vaginal sex in the past week.Conclusions:
A substantial proportion of HPV DNA detections may be depositions due to recent unprotected vaginal sex.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Conducta Sexual
/
Parejas Sexuales
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Infecciones por Papillomavirus
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Alphapapillomavirus
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
País como asunto:
America do norte
Idioma:
En
Año:
2017
Tipo del documento:
Article