Inhibition of the transforming growth factor-ß/SMAD cascade mitigates the anti-neurogenic effects of the carbamate pesticide carbofuran.

Seth, Brashket; Yadav, Anuradha; Agarwal, Swati; Tiwari, Shashi Kant; Chaturvedi, Rajnish Kumar

Seth, Brashket; Yadav, Anuradha; Agarwal, Swati; Tiwari, Shashi Kant; Chaturvedi, Rajnish Kumar.

Seth B; From the Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Yadav A; the Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Lucknow Campus, Lucknow 226001, Uttar Pradesh, India.
Agarwal S; From the Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Tiwari SK; the Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Lucknow Campus, Lucknow 226001, Uttar Pradesh, India.
Chaturvedi RK; From the Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.

J Biol Chem ; 292(47): 19423-19440, 2017 11 24.

Article en En | MEDLINE | ID: mdl-28982980

Asunto(s)

Carbofurano/farmacología; Hipocampo/efectos de los fármacos; Células-Madre Neurales/efectos de los fármacos; Neurogénesis/efectos de los fármacos; Neuronas/efectos de los fármacos; Proteína smad3/antagonistas & inhibidores; Factor de Crecimiento Transformador beta/antagonistas & inhibidores; Animales; Diferenciación Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Proteína Doblecortina; Femenino; Hipocampo/citología; Hipocampo/metabolismo; Células-Madre Neurales/citología; Células-Madre Neurales/metabolismo; Neuronas/citología; Neuronas/metabolismo; Ratas; Ratas Wistar; Transducción de Señal

Palabras clave

neural stem cell (NSC); neurite outgrowth; neurodegeneration; neurogenesis; neuroprotection; neurotoxicity; pesticide; stem cells; toxicity; toxicology

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carbofurano / Factor de Crecimiento Transformador beta / Proteína smad3 / Neurogénesis / Células-Madre Neurales / Hipocampo / Neuronas Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article

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