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[Mechanism of migration and release of high mobility group box-1].
Zhao, Xin; Lü, Ben; Wang, Erhua.
  • Zhao X; Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013; Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
  • Lü B; Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013; Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
  • Wang E; Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 42(9): 1111-1115, 2017 Sep 28.
Article en Zh | MEDLINE | ID: mdl-28989160
ABSTRACT
High mobility group box-1 (HMGB1) is an evolutionarily conserved protein, which widely exists in mammals. HMGB1 contains the nucleus localization sequences. Intracellular and extracellular HMGB1 shows different biological functions. Extracellular HMGB1 is closely related to sepsis, cancer, rheumatoid immune, atherosclerosis, ischemia-reperfusion injury and so on. The mobilization of HMGB1 from the nucleus to the cytoplasm and subsequent release involves the processes of post-translation modification, active secretion and nuclear localization.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transporte de Proteínas / Proteína HMGB1 Límite: Animals / Humans Idioma: Zh Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transporte de Proteínas / Proteína HMGB1 Límite: Animals / Humans Idioma: Zh Año: 2017 Tipo del documento: Article