The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells.
Nano Lett
; 17(11): 6941-6948, 2017 11 08.
Article
en En
| MEDLINE
| ID: mdl-29022351
ABSTRACT
Cell migration and mechanics are tightly regulated by the integrated activities of the various cytoskeletal networks. In cancer cells, cytoskeletal modulations have been implicated in the loss of tissue integrity and acquisition of an invasive phenotype. In epithelial cancers, for example, increased expression of the cytoskeletal filament protein vimentin correlates with metastatic potential. Nonetheless, the exact mechanism whereby vimentin affects cell motility remains poorly understood. In this study, we measured the effects of vimentin expression on the mechano-elastic and migratory properties of the highly invasive breast carcinoma cell line MDA231. We demonstrate here that vimentin stiffens cells and enhances cell migration in dense cultures, but exerts little or no effect on the migration of sparsely plated cells. These results suggest that cell-cell interactions play a key role in regulating cell migration, and coordinating cell movement in dense cultures. Our findings pave the way toward understanding the relationship between cell migration and mechanics in a biologically relevant context.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vimentina
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Neoplasias de la Mama
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Movimiento Celular
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Invasividad Neoplásica
Límite:
Female
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article