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Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic ß-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity.
Rajasekaran, Subu Surendran; Illies, Christopher; Shears, Stephen B; Wang, Huanchen; Ayala, Thais S; Martins, Joilson O; Daré, Elisabetta; Berggren, Per-Olof; Barker, Christopher J.
  • Rajasekaran SS; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
  • Illies C; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
  • Shears SB; Signal Transduction Laboratory/Inositol Signaling Group, NIEHS, Building 101, Room F239, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Wang H; Signal Transduction Laboratory/Inositol Signaling Group, NIEHS, Building 101, Room F239, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Ayala TS; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Martins JO; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Daré E; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
  • Berggren PO; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address: per-olof.berggren@ki.se.
  • Barker CJ; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address: chris.barker@ki.se.
Cell Signal ; 42: 127-133, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29042286
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Fosfotransferasas (Aceptor del Grupo Fosfato) / Inhibidores Enzimáticos / Células Secretoras de Insulina / Fosfatos de Inositol Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Fosfotransferasas (Aceptor del Grupo Fosfato) / Inhibidores Enzimáticos / Células Secretoras de Insulina / Fosfatos de Inositol Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article