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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Turnbull, Andrew P; Ioannidis, Stephanos; Krajewski, Wojciech W; Pinto-Fernandez, Adan; Heride, Claire; Martin, Agnes C L; Tonkin, Louise M; Townsend, Elizabeth C; Buker, Shane M; Lancia, David R; Caravella, Justin A; Toms, Angela V; Charlton, Thomas M; Lahdenranta, Johanna; Wilker, Erik; Follows, Bruce C; Evans, Nicola J; Stead, Lucy; Alli, Cristina; Zarayskiy, Vladislav V; Talbot, Adam C; Buckmelter, Alexandre J; Wang, Minghua; McKinnon, Crystal L; Saab, Fabienne; McGouran, Joanna F; Century, Hannah; Gersch, Malte; Pittman, Marc S; Marshall, C Gary; Raynham, Tony M; Simcox, Mary; Stewart, Lorna M D; McLoughlin, Sheila B; Escobedo, Jaime A; Bair, Kenneth W; Dinsmore, Christopher J; Hammonds, Tim R; Kim, Sunkyu; Urbé, Sylvie; Clague, Michael J; Kessler, Benedikt M; Komander, David.
  • Turnbull AP; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • Ioannidis S; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Krajewski WW; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • Pinto-Fernandez A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
  • Heride C; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
  • Martin ACL; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Tonkin LM; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Townsend EC; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Buker SM; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Lancia DR; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Caravella JA; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Toms AV; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Charlton TM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
  • Lahdenranta J; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Wilker E; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Follows BC; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Evans NJ; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • Stead L; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
  • Alli C; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Zarayskiy VV; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Talbot AC; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Buckmelter AJ; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Wang M; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • McKinnon CL; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Saab F; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • McGouran JF; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
  • Century H; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
  • Gersch M; Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Pittman MS; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • Marshall CG; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Raynham TM; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • Simcox M; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Stewart LMD; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • McLoughlin SB; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Escobedo JA; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Bair KW; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Dinsmore CJ; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Hammonds TR; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.
  • Kim S; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA.
  • Urbé S; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
  • Clague MJ; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
  • Kessler BM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
  • Komander D; Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Nature ; 550(7677): 481-486, 2017 10 26.
Article en En | MEDLINE | ID: mdl-29045389
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Pirazoles / Pirimidinas / Peptidasa Específica de Ubiquitina 7 Límite: Animals / Female / Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Pirazoles / Pirimidinas / Peptidasa Específica de Ubiquitina 7 Límite: Animals / Female / Humans Idioma: En Año: 2017 Tipo del documento: Article