Ral signaling pathway in health and cancer.
Cancer Med
; 6(12): 2998-3013, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-29047224
ABSTRACT
The Ral (Ras-Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and malignant peripheral nerve sheath tumors. Additionally, we have shown that the activation of RalA in cancer stem cells is higher in comparison with differentiated cancer cells. In this article, we review the role of Ral signaling in health and disease with a focus on the role of this multifunctional protein in the generation of therapies for cancer. An improved understanding of this pathway can lead to development of a novel class of anticancer therapies that functions on the basis of intervention with RalA or its downstream effectors.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
/
Proteínas de Unión al GTP ral
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article