Brain penetration of orally administered sodium pyroglutamate.
J Pharm Pharmacol
; 40(8): 584-5, 1988 Aug.
Article
en En
| MEDLINE
| ID: mdl-2907018
ABSTRACT
The absorption and brain penetration of [3H]pyroglutamate was determined after oral administration to rats. Gas-liquid chromatography of the methylated derivatives followed by mass fragmentometry was used to analyse the plasma and brain levels of pyroglutamate. [3H]Pyroglutamate was separated from other labelled compounds by thin layer chromatography. The administration of 500 mg kg-1 [3H]pyroglutamate resulted in a 30-fold increase in plasma levels and a doubling in the brain levels. Over 60% of the cerebral radioactivity was present as [3H]pyroglutamate demonstrating that pyroglutamate is not only well absorbed but also penetrates in significant amounts into the brain.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Pirrolidinonas
/
Ácido Pirrolidona Carboxílico
/
Encéfalo
Límite:
Animals
Idioma:
En
Año:
1988
Tipo del documento:
Article