TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.

Leyns, Cheryl E G; Ulrich, Jason D; Finn, Mary B; Stewart, Floy R; Koscal, Lauren J; Remolina Serrano, Javier; Robinson, Grace O; Anderson, Elise; Colonna, Marco; Holtzman, David M

Leyns, Cheryl E G; Ulrich, Jason D; Finn, Mary B; Stewart, Floy R; Koscal, Lauren J; Remolina Serrano, Javier; Robinson, Grace O; Anderson, Elise; Colonna, Marco; Holtzman, David M.

Leyns CEG; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Ulrich JD; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.
Finn MB; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110.
Stewart FR; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Koscal LJ; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.
Remolina Serrano J; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110.
Robinson GO; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Anderson E; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.
Colonna M; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110.
Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.

Proc Natl Acad Sci U S A ; 114(43): 11524-11529, 2017 10 24.

Article en En | MEDLINE | ID: mdl-29073081

Asunto(s)

Inflamación/genética; Glicoproteínas de Membrana/metabolismo; Enfermedades Neurodegenerativas/genética; Receptores Inmunológicos/metabolismo; Tauopatías; Animales; Regulación de la Expresión Génica/fisiología; Glicoproteínas de Membrana/genética; Ratones; Ratones Noqueados; Ratones Transgénicos; Receptores Inmunológicos/genética

Palabras clave

Alzheimer's disease; TREM2; neurodegeneration; neuroinflammation; tau

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Enfermedades Neurodegenerativas / Tauopatías / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google