Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers.
Pharmacology
; 101(1-2): 86-91, 2018.
Article
en En
| MEDLINE
| ID: mdl-29131129
ABSTRACT
AIM:
To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.METHODS:
This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30.RESULTS:
A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected.CONCLUSIONS:
In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
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Diazepam
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Frecuencia Cardíaca
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Hipnóticos y Sedantes
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2018
Tipo del documento:
Article