Frequency of brain MRI abnormalities in neuromyelitis optica spectrum disorder at presentation: A cohort of Latin American patients.
Mult Scler Relat Disord
; 19: 73-78, 2018 Jan.
Article
en En
| MEDLINE
| ID: mdl-29156226
ABSTRACT
BACKGROUND:
Brain magnetic resonance imaging (BMRI) lesions were classically not reported in neuromyelitis optica (NMO). However, BMRI lesions are not uncommon in NMO spectrum disorder (NMOSD) patients.OBJECTIVE:
To report BMRI characteristic abnormalities (location and configuration) in NMOSD patients at presentation.METHODS:
Medical records and BMRI characteristics of 79 patients with NMOSD (during the first documented attack) in Argentina, Brazil and Venezuela were reviewed retrospectively.RESULTS:
BMRI abnormalities were observed in 81.02% of NMOSD patients at presentation. Forty-two patients (53.1%) showed typical-NMOSD abnormalities. We found BMRI abnormalities at presentation in the brainstem/cerebellum (n = 26; 32.9%), optic chiasm (n = 16; 20.2%), area postrema (n = 13; 16.4%), thalamus/hypothalamus (n = 11; 13.9%), corpus callosum (n = 11; 13.9%), periependymal-third ventricle (n = 9; 11.3%), corticospinal tract (n = 7; 8.8%), hemispheric white matter (n = 1; 1.2%) and nonspecific areas (n = 49; 62.03%). Asymptomatic BMRI lesions were more common. The frequency of brain MRI abnormalities did not differ between patients who were positive and negative for aquaporin 4 antibodies at presentation.CONCLUSION:
Typical brain MRI abnormalities are frequent in NMOSD at disease onset.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
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Encéfalo
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Neuromielitis Óptica
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Acuaporina 4
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País como asunto:
America do sul
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Argentina
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Brasil
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Venezuela
Idioma:
En
Año:
2018
Tipo del documento:
Article